England batsman Zak Crawley has been ruled out of the first two Tests against India after a scan showed he has sprained his wrist.
The 23-year-old slipped outside the changing rooms during Tuesday's practice session.
Crawley, who opened in England's 2-0 Test series win in Sri Lanka in January, was set to bat at three to accommodate the returning Rory Burns.
Ollie Pope will likely deputise after recovering from a shoulder injury.
England also have Ben Stokes and Jofra Archer returning for the four-Test series, which begins on Friday.
"You feel for players who pick these injuries up - doing everything they can to get ready, and something as freak as that can have such a big impact," said England captain Joe Root, who will play his 100th Test.
On Pope's return, Root told the BBC: "It's a really exciting time to see him back in the fold."