Courtney Lawes will captain England in Saturday's first Test against Australia, as veterans Danny Care and Billy Vunipola also start.
Lawes leads the side in Perth ahead of ex-skipper Owen Farrell, who is back at inside centre following injury.
Scrum-half Care will win his first cap in almost four years, while number eight Vunipola's brother Mako is among the replacements.
Marcus Smith starts at 10 and uncapped wing Henry Arundell is on the bench.
England team to face Australia: Steward; Nowell, Marchant, Farrell, Cokanasiga; Smith, Care; Genge, George, Stuart, Itoje, Hill, Lawes (capt), Curry, B Vunipola.
Replacements: Cowan-Dickie, M Vunipola, Heyes, Chessum, Ludlam, Van Poortlviet, Porter, Arundell.