The relegation battle has seen twists and turns all season but it will come down to the final day to decide which two other teams go down from the Premier League.
It will be a nerve-wracking weekend for supporters of Everton, Leicester City and Leeds United as all three remain in the thick of it, potentially joining already relegated Southampton.
Everton are the only team who can control their destiny and not rely on other results after Leicester missed an opportunity to take matters into their own hands with a goalless draw against Newcastle on Monday evening.
The Toffees scored a 99th-minute equaliser against Wolves on Saturday but they need a victory at home to Bournemouth this weekend to confirm their safety.
Draw or lose, and the opportunity opens up for Leicester or Leeds - but those teams must win their home matches against West Ham and Tottenham respectively to stand a chance.
Leeds slipped to a costly 3-1 defeat against West Ham on Sunday, leaving them two points behind Everton in 19th place. Leicester sit 18th, also two points behind Everton.
Southampton's 11-year stay in the Premier League ended in tame fashion earlier this month with a 2-0 defeat at home by Fulham.
Everton podcaster Ped McPartland tells The Football News Show his club are "facing a crisis"
Everton's results improved after Sean Dyche became manager at the end of January following the sacking of Frank Lampard, but not enough to steer them clear of trouble.
They were seconds away from defeat against Wolves, but only time will tell how crucial Yerry Mina's late goal will be.
"The mood around Goodison Park would have hit the floor had they left Molineux with the defeat that would have left their Premier League existence even more fragile," said BBC Sport chief football writer Phil McNulty.
"Instead, Mina pounced in a crowded scene to give Everton a point that may yet prove priceless as they go into their final home game against Bournemouth.
"Goodison Park will be full of passion next Sunday as Everton hope they can make their third last-day escape of the Premier League era."
Still to play: 28 May: Bournemouth (h)
Gracenote chance of relegation: 21%
Leicester City and Leeds United are currently in the bottom three heading into the final weekend
Leicester finished eighth last season and reached the Europa Conference League semi-finals, but they made an awful start to this campaign, picking up only one point in their first seven matches.
Manager Brendan Rodgers has been replaced by Dean Smith until the end of the season, but they have dropped into the relegation places.
Leicester have an array of attacking talent, but their problem has been conceding goals, having kept one clean sheet in their past 21 matches.
Still to play: 28 May: West Ham (h)
Gracenote chance of relegation: 83%
Leeds won 2-1 at Brentford on the last day of the 2021-22 season to stay in the Premier League and relegate Burnley
Jesse Marsch was sacked as manager in February with Leeds on a seven-game winless run but, after an encouraging start, things got tough for new boss Javi Gracia and he was subsequently replaced by Sam Allardyce.
Leeds boosted their survival hopes with a spirited 2-2 draw at home to Newcastle at Elland Road, but Sunday's defeat away at West Ham means their fate is now out of their hands.
The Whites finish the season at home to Tottenham Hotspur.
Winger Luis Sinisterra, whose goal against Leicester on 25 April was his third in five games, isn't available for the run-in owing to an ankle ligament injury, but Junior Firpo is available for the Spurs game after missing the West Ham defeat with a one-game ban.
Still to play: 28 May: Tottenham (h)
Gracenote chance of relegation: 95%
Relegated
Southampton will be playing Championship football in 2023-24 after a 2-0 loss to Fulham on Saturday extended their winless streak to 11, including eight defeats, and confirmed their relegation.
They are another side on their third manager of the season after they sacked Ralph Hasenhuttl in November.
He was replaced by Nathan Jones, who only lasted eight Premier League matches and picked up one win before he was also dismissed.
Ruben Selles, assistant manager under Hasenhuttl, was next in line, but he has not been able to keep them up.
Still to play: 28 May: Liverpool (h)