Flanker Justin Tipuric returns from illness in the only Wales change for the Autumn Nations Cup opener against Ireland in Dublin on Friday.
Coach Wayne Pivac reverts to the side initially picked against Scotland with Tipuric ruled out on the morning of that defeat by tonsillitis.
Uncapped Bristol fly-half Callum Sheedy is on the bench, named in Wales' matchday squad for the first time.
George North will play his 100th Test if he comes on as a replacement.
Ospreys wing has won 96 Wales caps and three for the British and Irish Lions.
Prop Tomas Francis will win his 50th cap, while new world record cap holder and Wales captain Alun Wyn Jones will play his 150th Test match.
More to follow.
Wales: Leigh Halfpenny; Liam Williams, Jonathan Davies, Owen Watkin, Josh Adams; Dan Biggar, Gareth Davies; Rhys Carre, Ryan Elias, Tomas Francis, Will Rowlands, Alun Wyn Jones (capt), Shane Lewis-Hughes, Justin Tipuric, Taulupe Faletau.