The loss for Cameroon comes five days before they plays their first match of the Confederations Cup in Moscow against Chile.

Rodriguez, who is likely leaving Spanish champions Real Madrid this summer, scored Colombia's opener at Getafe's Alfonso Perez Coliseum.

Rodriguez then set up Yerry Mina by sending over a corner kick for the Palmeiras defender to head home near the half-hour mark.

Cameroon were reduced to 10 men when Robert Tambe was sent off early in the second half, before Mina struck with a second header, this time from a corner taken by Giovanni Moreno.

Jose Izquierdo finished off the victory with a late goal.

This was Colombia's second friendly in Spain in a week. They drew 2-2 with Spain's national side last Wednesday in Murcia.

Colombia next face World Cup qualifiers against Venezuela on Aug. 31 and Brazil on Sept. 5.