South African officials declared the border area with Zimbabwe as a cholera disaster region on Thursday.
South Africa's Limpopo provincial government declared the cholera-hit Vhembe area a disaster area, the office of the provincial premier said.
The Vhembe area which includes Musina town and Madimbo has thousands of patients infected with cholera. The executive council met in Polokwane to find solutions to the outbreak which has claimed eight lives, the SABC said.
Out of eight people who had already died of cholera, six were Zimbabwean nationals while two were South Africans.
Spokesman Mogale Nchabeleng said the Limpopo Executive Council took the decision at the Peter Mokaba stadium after the Department of Health and Social Development presented a report on how the provincial government was responding to the challenge.
"The report indicated that with the massive influx of Zimbabwean nationals, most people are infected with cholera bacteria. To date, no less than 664 people have been treated with cholera and practitioners are gradually finding it difficult to cope with the numbers," Nchabeleng said.
"The report also indicated that although the situation has been under control, more resources, human and capital, are required if we are to make the necessary impact in our fight against this monster that continues afflict humanity in this northern part of the province," he said.
Earlier on Wednesday, the Limpopo health department said the number of Musina cholera cases had risen to 664 overnight, from 645.

Spokesman Phuthi Seloba said that although there was a rise in suspected cases from Tuesday, the death toll remained at eight.
The increase comes after Health Minister Barbara Hogan led a team of health experts to assess the cholera outbreak in Limpopo on Tuesday.
The outbreak began on November 15 after Zimbabweans affected by the disease in their country crossed the boarder to seek treatment from the South African province.
The United Nations has also released statistics that showed Zimbabwe's cholera death toll has gone up to 746 with 15,572 suspected cases.