The Ghanaian government has said that from midnight on Sunday all visitors to the country need to be fully vaccinated against before being allowed to enter.
Ghanaians who intend to return to the country in the next fortnight are exempted, but will be vaccinated upon arrival, a statement from the country's health service says.
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"All Ghanaians travelling out of the country are to be fully vaccinated," the statement adds.
The order is part of measures to help control the spread of the Omicron variant of Covid-19.
The health service statement says that most cases of the variant in the country were from people who had arrived at the international airport in Accra - and the majority of those people had been unvaccinated.
Ghana has recorded just over 130,000 cases of coronavirus in total and 1,200 deaths.