Sekyere South District formerly Afigya Sekyere District is located in the north eastern part of the Ashanti Region. Agona Ashanti, the administrative capital, is located 37 kilometres away from Kumasi, along the Kumasi – Mampong trunk road.

The district shares common borders with Ejura Sekyedumasi, Mampong Municipal and Sekyere East to the east, Kwabre East to the south and Offinso Municipal to the west..