Sekyere Afram Plains District is located between latitude 0° 20’ N and 1° 20’ N and longitudes 6° 52’ W and 7° 32’ W. It covers an estimated land area of 3,500.56 square kilometers.

The district shares common boundaries with other districts in the region. They are Sekyere Central to the West, Sekyere East.

and Asante Akim North Districts to the South.