Lionel Messi shrugged off the frustration of missing a penalty to reach another remarkable career landmark as Barcelona eased to a 2-0 victory at Alaves.
Messi, who hit the woodwork three times in the 2-0 win over Real Betis on the opening day of the season, saw his first-half spot-kick superbly saved by Fernando Pacheco after Gerard Pique had been pulled down in the penalty area.
But the 30-year-old was not be denied the 350th LaLiga goal of his career and added the 351st for good measure as the visitors ran out comfortable winners.
It took until the 54th minute for Barcelona to break the deadlock, Messi reacting quickest to gather Jordi Alba's cross and fire a left-footed shot which flicked off Alexis Ruano and beat Pacheco at his near post.
Alaves then gifted Barcelona a second goal when Pedraza and Alexis failed to clear the ball on the edge of their area and allowed substitute Paco Alcacer to
Messi scored the milestone goal in La Liga more than 12 years after his first, when he was only 17. He has 66 more than Real Madrid's Cristiano Ronaldo, his closest challenger in the all-time list.
Messi, who has at least one league goal in 14 straight seasons, is only the second player to have surpassed 350 goals in the top five European leagues, after Bayern Munich's Gerd Mueller, who ended his career with 365 in the Bundesliga.
Atletico Madrid scored twice in the first five minutes on their way to an emphatic 5-1 win at Las Palmas.
Angel Correa and Yannick Carrasco fired Atletico into an early 2-0 lead, before former West Ham loanee Jonathan Calleri pulled a goal back for Las Palmas in the 58th minute.
But the visitors sealed the points through Koke's double and, after Jonathan Viera was denied by Jan Oblak from the penalty spot nine minutes from time, Thomas Partey added a fifth at the death.
Elsewhere on Saturday, Girona earned their first-ever Primera Division win, beating Malaga 1-0 to remain unbeaten after an opening draw a week ago.
Pedro Alcala put in a rebound for the only goal in the 28th minute for Girona, who on Wednesday were taken over by the City Football Group that also controls Manchester City.
Ivi scored a late penalty to help 10-man Levante salvage a 2-2 draw at home against Derpotivo La Coruna.
Federico Cartabia put Depor ahead after just five minutes and Sidnei doubled the lead on the half-hour mark, but Enis Bardhi was quickly able to pull one back from a free kick for the hosts.
And though Jose Luis Morales received a pair of red cards in a nine-minute span, Ivi netted the equaliser in the 83rd minute after drawing a foul from Juanfran.