Rishi Sunak will call on Thursday for more co-ordinated European action to tackle the rising numbers of irregular migrants arriving on the continent's borders.
At a special summit of European leaders in Spain, the prime minister will say the situation is "immoral and unsustainable".
He will demand "creative Europe-wide solutions" to the continent's migration crisis, which for him means tackling people smugglers and tightening borders.
Mr Sunak will co-chair a leaders' meeting with Georgia Meloni, the prime minister of Italy, which has already seen more than 100,000 migrants land on its shores this year - five times as much as the UK.
And he will agree deals with the leaders of Belgium, Bulgaria and Serbia to disrupt criminal networks by sharing more intelligence and co-operating more at an operational level. Serbia in particular is a key transit country for many migrants entering Europe.
The summit of 47 EU and non-EU leaders is a gathering of what's called the European Political Community, a new body set up last year in the wake of Russia's invasion of Ukraine. Its chief focus is to discuss the war but it is also an opportunity for leaders to have wider, more informal discussions.
Although Mr Sunak used his party conference speech to argue against Britain aligning more closely with the European Union, he does appear more willing to co-operate with broader European partners on immigration, one of his key electoral priorities.
He has promised to stop the small boats containing migrants arriving across the English Channel. Although numbers are down compared to last year, more than 20,000 people have already arrived so far this year.
What is not clear yet is how many European leaders share Mr Sunak's priorities and whether more collective action might be possible. EU countries in particular have often struggled to agree how to share the burdens of migration.
The EU on Wednesday did agree to reform its internal asylum rules to make it easier for countries like Italy and Greece to get help from other members of the bloc when there is a surge in irregular migration. And diplomats say that some EU countries - including Spain - also want to discuss new methods of legal migration.
But Mr Sunak's focus is on addressing what he says are the root causes of the problem, namely criminal people smugglers, and that would require more co-ordinated action by non-EU as well as EU countries.
In remarks released by Downing Street, Mr Sunak said: "Levels of illegal migration to mainland Europe are the highest they have been in nearly a decade. With thousands of people dying at sea, propelled by people smugglers, the situation is both immoral and unsustainable. We cannot allow criminal gangs to decide who comes to Europe's shores.
"When it comes to facing down the threat from [Russian President Vladimir] Putin, confronting the risks and opportunities of AI or dealing with illegal migration, there is strength in unity.
"These issues transcend national borders and require creative Europe-wide solutions - that is what I will be discussing with my fellow leaders at the European Political Community summit in Spain today."
Mr Sunak is also expected to announce further humanitarian aid for Ukraine and discuss ways Western allies can help the country boost its grain exports.
The Foreign Office has released intelligence which, it claims, shows Russia is preparing to lay sea mines outside Ukrainian ports.
The aim, the Foreign Office says, is to deter the export of Ukrainian grain by targeting civilian shipping travelling through the Black Sea.