“Over the past decade, great progress has been made against NTDs, but there is still a lot more work to be done. Novartis will continue progressing our longstanding commitment to helping realize a world free of NTDs,” said Vas Narasimhan, CEO of Novartis. “Today, by endorsing the Kigali Declaration and pledging to invest USD 250 million, we aim to accelerate progress toward elimination of these diseases, which continue to cause suffering and stigma for millions of people around the globe.”

Novartis was among the original endorsers of the London Declaration on NTDs in 2012, committing to a multidrug therapy (MDT) donation to support global efforts to eliminate leprosy. This was followed with a commitment of USD 100 million toward the fight against malaria at the Malaria Summit in London in 2018. By endorsing the Kigali Declaration today, Novartis reaffirms its commitment to the fight against NTDs and malaria.

As part of the commitment over five years (2021-2025), Novartis will invest USD 250 million to advance research and development (R&D) of new treatments to combat NTDs and malaria.

This includes USD 100 million to advance R&D of its neglected tropical disease program, focusing on novel drug candidates for four diseases. In collaboration with Welcome, the Novartis Institute for Tropical Diseases (NITD) is working to discover novel, curative antiparasitic therapies for Chagas disease. Further, we are collaborating with the Drugs for Neglected Diseases Initiative (DNDi), with earlier support from Wellcome, to jointly develop LXE408 for the treatment of visceral leishmaniasis, and are currently entering Phase II clinical development. We also made progress on a potential first-in-class compound to treat dengue fever, which is currently in Phase I clinical trial. Although this is the most common vector-borne viral disease in the world, there is currently no specific treatment for dengue. Cryptosporidium infection is the most prevalent form of parasitic diarrhea, a major cause of mortality among young children in developing countries. The NITD has discovered a promising drug candidate, EDI048, currently in Phase I clinical development.

With regards to malaria, Novartis commits to investing USD 150 million to advance the clinical development programs of its three novel drug candidates to combat the emerging resistance

to artemisinin. The company will also continue with activities to support the development of an optimized formulation for neonates and infants under 5kg, for whom no treatment currently exists.

Around the world, 1.7 billion people suffer from NTDs, which are prevalent in tropical areas and mostly affect impoverished communities, causing devastating health, social and economic consequences. The NITD was established in 2001 within the Novartis Institutes for BioMedical Research (NIBR) to apply modern drug discovery technologies to finding new therapeutics for NTDs and malaria.

Novartis has been committed to the fight against malaria for more than 20 years and to date, working with partners, the company has delivered more than 1 billion treatments, including more than 450 million pediatric treatments, without profit to malaria-endemic countries. According to the 2021 World Malaria Report, there were 241 million cases of malaria and 627,000 malaria deaths in 2020. Children under 5 are particularly at risk, and malaria takes the life of a child every minute in Africa.

For more information on our work in NTDs: Novartis Institute for Tropical Diseases | Novartis

For more information on our work in malaria: www.malaria.novartis.com

Distributed by African Media Agency (AMA) on behalf of Novartis.

About Novartis

Novartis is reimagining medicine to improve and extend people’s lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world’s top companies investing in research and development. Novartis products reach nearly 800 million people globally and we are finding innovative ways to expand access to our latest treatments. About 108,000 people of more than 140 nationalities work at Novartis around the world.

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References

1. https://unitingtocombatntds.org/ntds/

2. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021