Researchers examined data on more than 190,000 adults from 10 different studies conducted in the U.S. over the past seven decades that looked at weight and other factors that can influence the risk of heart disease. None of the participants had cardiovascular disease when they joined these studies, but at least 70 percent of men and about 60 percent of women aged 40 and older were overweight or obese.

For middle-aged men 40 to 59 years old, the odds of having a stroke, heart attack, heart failure or death from cardiovascular causes was 21 percent higher for overweight individuals than for those at a normal weight, the study found. Overweight middle-aged women had 32 percent higher odds of having a heart condition or dying from it.

When middle-aged people were obese, men were 67 percent more likely to have a heart attack, stroke, heart failure or cardiovascular death and women had 85 percent higher odds compared to normal-weight peers.

Extremely obese middle-aged men had almost triple the risk of having a heart condition or dying from it, compared with normal-weight men, and extremely obese middle-aged women had more than twice the risk of normal-weight women.

“Our data clearly show that obesity is associated with a shorter, sicker life with more cardiovascular disease and more years lived with cardiovascular disease,” said lead study author Dr. Sadiya Khan of the Northwestern University Feinberg School of Medicine in Chicago.

“Obesity or excess fat in the body can increase risk for heart disease in and of itself as well as increasing risk for heart disease by causing elevated blood pressure, diabetes and abnormal cholesterol,” Khan said by email.

Some research in recent years has suggested that overweight people may live longer than their normal-weight counterparts, a phenomenon often described as the “obesity paradox.” Much of this research didn’t account for how early in life people develop ill health, however, and the current study offers fresh evidence linking excess weight to an increased risk of developing cardiovascular disease and of dying from it, researchers note in JAMA Cardiology.

The current study also links obesity to a shorter life.

While overweight men had a similar lifespan to normal-weight men, obese men lived 1.9 fewer years, and extremely obese men died six years sooner.

Middle-aged women who were a normal weight lived 1.4 years longer than overweight women, 3.4 years longer than obese women and six years longer than extremely obese women.

The study wasn’t a controlled experiment designed to prove whether or how obesity impacts the chance of developing cardiovascular disease or dying from it.

Another limitation is that researchers only had data on weight when people joined the studies, but not on any weight fluctuations over time. The study also assessed obesity using body mass index (BMI), a measure of weight relative to height that doesn’t take into account how much lean muscle versus fat people have.

A BMI between 18.5 and 24.9 is considered a healthy weight, 25 to 29.9 is overweight, 30 or above is obese and 40 or higher is what’s known as morbidly or extremely obese.

An adult who is 5’ 9” tall and weighs from 125 to 168 pounds would have a healthy weight and a BMI of 18.5 to 24.9, according to the U.S. Centers for Disease Control and Prevention. An obese adult at that height would weigh at least 203 pounds and have a BMI of 30 or more.

Results from the current study suggest there are no health benefits to a higher BMI, said Dr. Haitham Ahmed, medical director of cardiac rehabilitation at the Cleveland Clinic in Ohio.

“This study showed that risk was highest in obese patients, but even overweight patients had increased risk of cardiovascular disease,” Ahmed, who wasn’t involved in the study, said by email. “So we certainly encourage weight loss down to a normal BMI.”